• May 27, 2016 News!The submission for Special Issue is officially open now!   [Click]
  • May 03, 2016 News!Vol.6, No.6 has been indexed by EI (Inspec).   [Click]
  • Mar 17, 2017 News!Vol.9, No.2 has been published with online version. 13 peer reviewed articles from 4 specific areas are published in this issue.   [Click]
General Information
Editor-in-chief
Prof. Wael Badawy
Department of Computing and Information Systems Umm Al Qura University, Canada
I'm happy to take on the position of editor in chief of IJCTE. We encourage authors to submit papers concerning any branch of computer theory and engineering.
IJCTE 2016 Vol.8(3): 190-197 ISSN: 1793-8201
DOI: 10.7763/IJCTE.2016.V8.1042

Investigating Combined Drug and Plasma Apheresis Therapy of HIV Infection by Double Compartment Cellular Automata Simulation

Sompop Moonchai and Yongwimon Lenbury
Abstract—It has become widely acknowledged that potent combination drug therapy of patients infected with Human Immunodeficiency Virus can significantly prolong life, but exerts detrimental effect on a patient’s quality of life. Lymph nodes and lymphatic tissue are busy sites of immunological activity. Germs are brought there by the cells of the immune system to be broken down and analyzed. However, clinics commonly used blood tests for viral load therein to assess the effect of drug therapy. We are therefore of the opinion that most cellular automata models in the past that only considered viral proliferation in the lymph node cannot give a sufficiently accurate picture of the dynamics of HIV infection, especially when the impact of treatments that combine both drugs and plasma apheresis are in question. We thus present a two-compartment cellular automata (CA) model, which simulates the dynamics of HIV infection in both the lymph node and blood compartments when drugs and plasma apheresis are applied simultaneously. It is found that the combined usage of these two types of therapy yields more favorable outcome than the sole use of plasma apheresis.

Index Terms—Cellular automata, HIV, HAART, plasma apheresis.

Sompop Moonchai is with the Department of Mathematics, Chiang Mai University, Chiang Mai, Thailand (e-mail: tumath@gmail.com).
Yongwimon Lenbury is with the Department of Mathematics, Faculty of Science, Mahidol University, Rama 6 Rd., Bangkok 10400, Thailand, and the Centre of Excellence in Mathematics, PERDO, CHE, Thailand (e-mail: scylb@yahoo.com).

[PDF]

Cite:Sompop Moonchai and Yongwimon Lenbury, "Investigating Combined Drug and Plasma Apheresis Therapy of HIV Infection by Double Compartment Cellular Automata Simulation," International Journal of Computer Theory and Engineering vol. 8, no. 3, pp. 190-197, 2016.

Copyright © 2008-2015. International Journal of Computer Theory and Engineering. All rights reserved.
E-mail: ijcte@vip.163.com